1-(2-(三氟甲基)-嘧啶-4-基)-乙酮合成路线 （共 2 条）
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=85°C; Inert atmosphereSealed tube;
2: With potassium fluoride in diethyl ether; N,N-dimethyl-formamide
T=20°C;
3: With hydrogenchloride in water; N,N-dimethyl-formamide; acetone
T=60°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine, E.; CHEN, Zhi; ERICKSON, Shawn, David; KIM, Kyungjin; LI, Hongju; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter, Michael; YI, Lin
Patent: WO2014/56958 A1, 2014 ;
Location in patent: Paragraph 0076; 0077; 0078 ;
反应条件
1: in diethyl ether; N,N-dimethyl-formamide
T=0 - 20°C; 0.25 h;
2: With ammonium chloride; water in diethyl ether; N,N-dimethyl-formamide
参考文献
BIOGEN IDEC MA INC
Patent: WO2006/26305 A1, 2006 ;
Location in patent: Page/Page column 36 ;
WO 2006/026305 A1
