(5-甲氧基-2-硝基苯基)甲醇合成路线 （共 10 条）
反应条件
1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C 2: hydrogen; sodium acetate; 20 PtO2/C / ethyl acetate / 0.5 h / 20 °C View Scheme
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
WO 2012/109108 A1
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 3 h;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED
Patent: WO2004/62665 A1, 2004 ;
Location in patent: Page/Page column 37 ;
WO 2004/062665 A1
反应条件
borane-THF in tetrahydrofuran
T=0°C; Reflux;
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
Location in patent: Page/Page column 39 ;
WO 2012/109108 A1
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran; methanol
3 h; Heating / reflux;
2: With sodium hydroxide; water in tetrahydrofuran; methanol
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/121152 A1, 2005 ;
Location in patent: Page/Page column 30; 31 ;
WO 2005/121152 A1
反应条件
potassium borohydride
参考文献
Bowman,R.E. et al.
Journal of the Chemical Society, 1965 , p. 1080 - 1087
反应条件
potassium carbonate in acetone
T=35 - 40°C; 46 h;
参考文献
Aujard, Isabelle; Benbrahim, Chouaha; Gouget, Marine; Ruel, Odile; Baudin, Jean-Bernard; Neveu, Pierre; Jullien, Ludovic
Chemistry - A European Journal, 2006 , vol. 12, # 26 p. 6865 - 6879
反应条件
sodium tetrahydroborate in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
Kataoka, Tadashi; Watanabe, Shin-Ichi; Mori, Eiji; Kadomoto, Ryoji; Tanimura, Susumu; Kohno, Michiaki
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2397 - 2407
反应条件
phosphorus tribromide in diethyl ether
3 h; Inert atmosphere;
参考文献
Kong, Chen; Jana, Navendu; Driver, Tom G.
Organic Letters, 2013 , vol. 15, # 4 p. 824 - 827
反应条件
hydrogen; 10 palladium on activated carbon in ethanol; water
P=3105.31 Torr; 1 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/121152 A1, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/121152 A1
反应条件
hydrogen; Adams' platinum oxide in ethanol
参考文献
Imperial Chemical Industries Limited
Patent: US4268510 A1, 1981 ;
