反应条件
1: 2-quinoxaline-carboxylic acid With 1,1'-carbonyldiimidazole in ethyl acetate
T=20 - 60°C; 2 h; Large scale;
2: (3R,5S)-5-(((S)-1-amino-2-(3-fluorophenyl)ethyl)dihydro-3-(3-hydroxy-3-methylbutyl)furan-2(3H)one) p-toluenesulfonic acid With triethylamine in ethyl acetate
T=20°C; 4 h; Large scale;
参考文献
Li, Bryan; Andresen, Brian; Brown, Matthew F.; Buzon, Richard A.; Chiu, Charles K.-F.; Couturier, Michel; Dias, Eric; Urban, Frank J.; Jasys, V. John; Kath, John C.; Kissel, William; Le, Tung; Li, Z. Jane; Negri, Joanna; Poss, Christopher S.; Tucker, John; Whritenour, David; Zandi, Kathleen
Organic Process Research and Development, 2005 , vol. 9, # 4 p. 466 - 471