4-溴-6,7-二甲氧基噌啉合成路线 （共 3 条）
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=20 - 50°C; 18 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2006/28957 A1, 2006 ;
Location in patent: Page/Page column 140 ;
WO 2006/028957 A1
反应条件
1: hydrogenchloride; sodium nitrite / water / 75 °C
2: phosphorus oxytribromide / acetonitrile / 70 °C
View Scheme
参考文献
Hu, Essa; Kunz, Roxanne K.; Rumfelt, Shannon; Chen, Ning; Buerli, Roland; Li, Chun; Andrews, Kristin L.; Zhang, Jiandong; Chmait, Samer; Kogan, Jeffrey; Lindstrom, Michelle; Hitchcock, Stephen A.; Treanor, James
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2262 - 2265
反应条件
1: 4-bromo-1H-indazole With n-butyllithium in isobutyramide
T=-30°C; 0.5 h;
2: 4-bromo-6,7-dimethoxycinnoline With triethylamine; tris-(dibenzylideneacetone)dipalladium(0) in isobutyramide
T=-30 - 85°C; 12.0833 h;
3: With methanol in dichloromethane
参考文献
AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/98214 A1, 2007 ;
Location in patent: Page/Page column 57; 69 ;
