4-氯-3-(2-吡啶)苯胺合成路线 （共 5 条）
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol; water
T=60°C; 1.5 h;
2: With sodium hydroxide in water
参考文献
Gunzner, Janet L.; Sutherlin, Daniel; Stanley, Mark S.; Bao, Liang; Castanedo, Georgette M.; Lalonde, Rebecca L.; Wang, Shumei; Reynolds, Mark E.; Savage, Scott J.; Malesky, Kimberly; Dina, Michael S.
Patent: US2006/63779 A1, 2006 ;
Location in patent: Page/Page column 74 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate in 1,4-dioxane; water
T=110°C;
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
Location in patent: Paragraph 0162; 0166 ;
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 8 h / 105 °C / |Inert atmosphere
2: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,4-dioxane / 110 °C
View Scheme
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
反应条件
1: iron; ammonium chloride / water; ethanol / 3 h / 75 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 8 h / 105 °C / |Inert atmosphere
3: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,4-dioxane / 110 °C
View Scheme
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0.5 h / -5 °C / |Cooling with ice
1.2: 3 h / 0 - 5 °C
2.1: iron; ammonium chloride / water; ethanol / 3 h / 75 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 8 h / 105 °C / |Inert atmosphere
4.1: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,4-dioxane / 110 °C
View Scheme
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
