(R)-1-boc-3-(cbz-氨基-甲基)-哌啶合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 16 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/28904 A1, 2006 ;
Location in patent: Page/Page column 257 ;
WO 2006/028904 A1
反应条件
1: NEt3 / CH2Cl2 / 1.5 h / 0 °C
2: sodium azide / dimethylformamide / 24 h / 50 °C
3: H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature
4: tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature
View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
1: H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature
2: tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature
View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
反应条件
1: sodium azide / dimethylformamide / 24 h / 50 °C
2: H2 / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature
3: tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature
View Scheme
参考文献
Hilpert; Ackermann; Banner; Gast; Gubernator; Hadvary; Labler; Muller; Schmid; Tschopp; Van de Waterbeemd
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3889 - 3901
