2-(2-(二氟甲基)苯基)-4,4,5,5-四甲基-1,3,2-二噁硼烷合成路线 （共 2 条）
反应条件
1: 1-bromo-2-(difluoromethyl)benzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Wilson, Dean; Fanning, Lev T.D.; Krenitsky, Paul; Termin, Andreas; Joshi, Pramod; Sheth, Urvi
Patent: US2008/167305 A1, 2008 ;
Location in patent: Page/Page column 56 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide
T=80°C; 10 h;
参考文献
PFIZER LIMITED
Patent: WO2008/135826 A2, 2008 ;
Location in patent: Page/Page column 157 ;
WO 2008/135826 A2
