(E)-5-氯-2-异丙基-4-戊烯酸合成路线 (共 7 条)
反应条件
methanol in hexane; ethyl acetate T=20°C; 1 h; Product distribution / selectivity;
参考文献
EP1961728 A1, ;
Page/Page column 8 ;
反应条件
1: With sodium hydroxide in water
T=100 - 110°C; P=2250.23 Torr; 2 h;
2: With sulfuric acid; water
pH=1.5; Product distribution / selectivity;
参考文献
DSM Fine Chemicals Austria NFG GMBH and Co KG
Patent: US2008/207943 A1, 2008 ;
Location in patent: Page/Page column 2 ;
反应条件
sodium hydroxide; water in ethanol
18 h; Heating / reflux;
参考文献
Speedel Pharma AG
Patent: EP1200384 B1, 2004 ;
Location in patent: Page 6 ;
反应条件
1: With sodium methylate in methanol; N,N-dimethyl-formamide
T=60°C;
2: With trans-3-chloroacrylyl chloride
T=80°C; 2.5 h;
3: With sodium hydroxide; sulfuric acid; water; calcium chloride
Product distribution / selectivity; more than 3 stages;
参考文献
DSM Fine Chemicals Austria NFG GMBH and Co KG
Patent: US2008/207943 A1, 2008 ;
Location in patent: Page/Page column 2-3 ;
反应条件
1: methyl 2-carbomethoxy-3-methylbutyrate With sodium methylate in methanol; N,N-dimethyl-formamide
T=60°C; 1 h;
2: trans-3-chloroacrylyl chloride T=80°C; 3 h;
3: With lithium chloride in methanol
T=140 - 142°C; 8 h;
参考文献
DSM Fine Chemicals Austria NFG GMBH and Co KG
Patent: US2008/207943 A1, 2008 ;
Location in patent: Page/Page column 2 ;
反应条件
1: With calcium chloride in methanol; N,N-dimethyl-formamide
T=140 - 145°C; 12 h;
2: With hydrogenchloride; water in tert-butyl methyl ether
3: With sodium hydroxide; sulfuric acid; water
Product distribution / selectivity; more than 3 stages;
参考文献
DSM FINE CHEMICALS AUSTRIA NFG GMBH and CO KG
Patent: WO2007/17018 A1, 2007 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: With methanol; lithium chloride in N,N-dimethyl-formamide
T=140 - 142°C; 8 h;
2: With hydrogenchloride; water in tert-butyl methyl ether
Product distribution / selectivity;
参考文献
DSM FINE CHEMICALS AUSTRIA NFG GMBH and CO KG
Patent: WO2007/17018 A1, 2007 ;
Location in patent: Page/Page column 7-8 ;