(9Z,11E,13S,15Z)-13-羟基-9,11,15-十八碳三烯酸合成路线 （共 15 条）
反应条件
1: 2) Et2NH, CuI / 1) Pd(PPh3)4 / 1) benzene, rt, 1 h, 2) 5 h
2: 91 percent / H2 / Lindlar catalyst / ethanol
3: 92 percent / n-Bu4NF / tetrahydrofuran / 12 h / Ambient temperature
4: 73 percent / K2CO3 / methanol; H2O / Ambient temperature
View Scheme
参考文献
Yadav; Deshpande; Sharma
Tetrahedron, 1992 , vol. 48, # 21 p. 4465 - 4474
反应条件
1: 91 percent / H2 / Lindlar catalyst / ethanol
2: 92 percent / n-Bu4NF / tetrahydrofuran / 12 h / Ambient temperature
3: 73 percent / K2CO3 / methanol; H2O / Ambient temperature
View Scheme
参考文献
Yadav; Deshpande; Sharma
Tetrahedron, 1992 , vol. 48, # 21 p. 4465 - 4474
反应条件
1: 92 percent / n-Bu4NF / tetrahydrofuran / 12 h / Ambient temperature
2: 73 percent / K2CO3 / methanol; H2O / Ambient temperature
View Scheme
参考文献
Yadav; Deshpande; Sharma
Tetrahedron, 1992 , vol. 48, # 21 p. 4465 - 4474
反应条件
1: With Physcomitrella patens lipoxygenase PpLOX6; oxygen
pH=7.0; 0.5 h; aq. phosphate bufferEnzymatic reaction;
2: With sodium tetrahydroborate in methanol
0.5 h; optical yield given as percent eeenantiospecific reaction;
参考文献
Anterola, Aldwin; Goebel, Cornelia; Hornung, Ellen; Sellhorn, George; Feussner, Ivo; Grimes, Howard
Phytochemistry, 2009 , vol. 70, # 1 p. 45 - 57
反应条件
1: With Physcomitrella patens lipoxygenase PpLOX2; oxygen
pH=7.0; 0.5 h; aq. phosphate bufferEnzymatic reaction;
2: With sodium tetrahydroborate in methanol
0.5 h; enantiospecific reaction;
参考文献
Anterola, Aldwin; Goebel, Cornelia; Hornung, Ellen; Sellhorn, George; Feussner, Ivo; Grimes, Howard
Phytochemistry, 2009 , vol. 70, # 1 p. 45 - 57
