5-溴-2-(3-甲基-[1,2,4]噁二唑-5-基)-吡啶合成路线 (共 2 条)
反应条件
1: 5-bromo-2-pyridinecarboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
1.5 h; Heating / reflux;
2: acetamide oxime in toluene
T=80°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/29906 A1, 2006 ;
Location in patent: Page/Page column 19 ;
WO 2006/029906 A1
反应条件
1: 5-bromo-2-pyridinecarboxylic acid; 1,1'-carbonyldiimidazole in tetrahydrofuran
1.5 h; Heating / reflux;
2: acetamide oxime in tetrahydrofuran
Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/40192 A1, 2006 ;
Location in patent: Page/Page column 39 ;
WO 2006/040192 A1