4-氯-3,5-二甲基苯酚合成路线 （共 35 条）
反应条件
(i) K2CO3, DMF, (ii) TsOH, toluene; Multistep reaction;
参考文献
Baker,B.R.; Neenan,J.P.
Journal of Medicinal Chemistry, 1972 , vol. 15, # 9 p. 940 - 944
反应条件
triethylamine; magnesium chloride in acetonitrile 4 h; Heating / reflux;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/87686 A2, 2004 ;
Location in patent: Page 253 ;
Title/Abstract Full Text Show Details
PHARMACIA CORPORATION
Patent: WO2004/87687 A1, 2004 ;
Location in patent: Page 253 ;
WO 2004/087687 A1
反应条件
titanium tetrachloride in dichloromethane
参考文献
ICI Australia Limited
Patent: US4666510 A1, 1987 ;
参考文献
Abbott Laboratories
Patent: US4312887 A1, 1982 ;
反应条件
boric acid; glycerol T=150 - 160°C; und anschliessendes Erwaermen mit wss.H2SO4;
参考文献
Duff
Journal of the Chemical Society, 1941 , p. 547,549
反应条件
sodium hydroxide; chloroform
参考文献
Duff
Journal of the Chemical Society, 1941 , p. 547,549
反应条件
hydrogenchloride; acetic acid
参考文献
Jones
Journal of the Chemical Society, 1941 , p. 267,269
Journal of the Chemical Society, 1942 , p. 676
Full Text Show Details
Gemmell
Manuf. Chemist, 1952 , vol. 23, p. 63
反应条件
potassium carbonate; isopropyl alcohol; palladium diacetate; triphenylphosphine T=90°C; 14 h;
参考文献
Tetrahedron, , vol. 63, # 20 p. 4266 - 4270
反应条件
1: |Inert atmosphere 2: cesium fluoride; C94H134O4P2Pd2 / toluene / 14 h / 110 °C / |Inert atmosphere View Scheme
参考文献
Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 21 p. 5602 - 5605
反应条件
in isopropyl alcohol T=74°C;
参考文献
Rivera, Augusto; Maldonado, Mauricio
Tetrahedron Letters, 2006 , vol. 47, # 42 p. 7467 - 7471
