4-氯-3,5-二甲基苯酚合成路线 （共 35 条）
反应条件
zinc(II) chloride
T=175°C;
参考文献
Klarmann; Shternov; Gates
Journal of the American Chemical Society, 1933 , vol. 55, p. 2576,2584
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Lehn and Fink Inc.
Patent: US1938912 , 1932 ;
反应条件
1: glacial acetic acid; concentrated aqueous HCl
2: chlorine
View Scheme
参考文献
Gemmell
Manuf. Chemist, 1952 , vol. 23, p. 63
参考文献
Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo
Green Chemistry, 2009 , vol. 11, # 7 p. 942 - 945
反应条件
potassium carbonate in acetone
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2004/14787 A1, 2004 ;
参考文献
v. Auwers
Fortsch. Ch., Phys., 1924 , vol. 18, p. 52
反应条件
1: conc. H2SO4, HOAc / 16 h / 22 °C
2: conc. HCl / ethanol / 1.5 h / Heating
3: NaOH, H2 / 5percent Pd/C / H2O / 1551.4 Torr
View Scheme
参考文献
Zigeuner; Jellinek
Monatshefte fuer Chemie, 1959 , vol. 90, p. 297,301
反应条件
1: ethanol
2: copper oxide-chromium oxide; dioxane / Hydrogenation
View Scheme
参考文献
Fitzgerald
Journal of Applied Chemistry, 1955 , vol. 5, p. 289,293
反应条件
1: sodium ethylate; ethanol
2: anschliessend mit 4-Chlor-benzylchlorid
View Scheme
参考文献
Weiss et al.
Journal of the American Pharmaceutical Association (1912-1977), 1951 , vol. 40, p. 267,268
反应条件
pyridine in benzene
1 h; Heating;
参考文献
Dupin, Jean-Francois E.; Chenault, Jacques
Heterocycles, 1983 , vol. 20, # 12 p. 2401 - 2404
反应条件
1: 99 percent / pyridine / benzene / 1 h / Heating
2: 60 percent / P2O5, 85percent H3PO4 / 1.5 h / 80 °C
View Scheme
参考文献
Dupin, Jean-Francois E.; Chenault, Jacques
Heterocycles, 1983 , vol. 20, # 12 p. 2401 - 2404
