2,4,6-三甲基苯胺合成路线 （共 254 条）
反应条件
1: 85 percent / CH2Cl2 / 0.5 h / Heating 2: 80 percent / toluene / 12 h / Heating View Scheme
参考文献
Lebedeva, A. S.; Chernyakova, I. V.; Likhosherstov, A. M.; Sipilina, N. M.; Ivanova, T. I.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 2 p. 79 - 83
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 2 p. 13 - 15
反应条件
1: 80 percent / propan-1-ol; H2O / 23 - 60 °C
2: 85 percent / sodium borohydride / tetrahydrofuran
3: 80 percent / formic acid / Heating
4: 72 percent / KH / tetrahydrofuran; various solvent(s) / 3 h / 23 °C
View Scheme
参考文献
Kolychev, Eugene L.; Asachenko, Andrey F.; Dzhevakov, Pavel B.; Bush, Alexander A.; Shuntikov, Viacheslav V.; Khrustalev, Victor N.; Nechaev, Mikhail S.
Dalton Transactions, 2013 , vol. 42, # 19 p. 6859 - 6866
反应条件
potassium acetate; copper diacetate
T=130°C;
参考文献
Shteinberg, Ya. B.; Tkachenko, S. S.
J. Appl. Chem. USSR (Engl. Transl.), 1980 , vol. 53, # 11 p. 2608 - 2612,1963 - 1965
反应条件
1: 89 percent / H2O; propan-2-ol / 24 h / 20 °C
2: 93 percent / NaBH4; HCl / tetrahydrofuran / 1.33 h / 0 - 20 °C
3: 96 percent / HCO2H / 5 h / 120 °C
4: 88 percent / potassium hydroxide / 1.25 h / 60 °C
View Scheme
参考文献
Trnka, Tina M.; Morgan, John P.; Sanford, Melanie S.; Wilhelm, Thomas E.; Scholl, Matthias; Choi, Tae-Lim; Ding, Sheng; Day, Michael W.; Grubbs, Robert H.
Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2546 - 2558
反应条件
diaminochlorophosphine ligand; sodium t-butanolate; [Pd(dibenzylideneacetone)2] in toluene
T=105°C; 21 h;
参考文献
Zhu, Lei; Ye, Yue-Mei; Shao, Li-Xiong
Tetrahedron, 2012 , vol. 68, # 10 p. 2414 - 2420
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate in toluene
T=20 - 105°C; Inert atmosphere;
参考文献
Ackermann, Lutz; Sandmann, Rene; Song, Weifeng
Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
反应条件
cesium fluoride in acetonitrile
T=20°C; 10 h;
参考文献
Liu, Zhijian; Larock, Richard C.
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3198 - 3209
反应条件
1: 2,4,6-trimethylbenzenamine With n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane
T=0 - 20°C; 0.5 h; Inert atmosphereSchlenk technique;
2: phenyl-magnesium bromide With N,N'-dimethyl-N,N'-propyleneurea; bis(acetylacetonate)nickel(II); 1,2-dichloro-2-methylpropane in tetrahydrofuran; hexane
T=0 - 20°C; 3 h; Inert atmosphereSchlenk technique;
参考文献
Ilies, Laurean; Matsubara, Tatsuaki; Nakamura, Eiichi
Organic Letters, 2012 , vol. 14, # 21 p. 5570 - 5573,4
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; sodium t-butanolate in 1,4-dioxane
T=75°C; 5 h; Molecular sieveSchlenk technique;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1448 - 1453
反应条件
tris-(dibenzylideneacetone)dipalladium(0); biphenyl-2-yl-di-tert-butyl-phosphane; sodium t-butanolate in toluene
T=100°C; 24 h; Inert atmosphereSealed tube;
参考文献
Hernandez-Perez, Augusto C.; Collins, Shawn K.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12696 - 12700
Angew. Chem., 2013 , vol. 125, # 48 p. 12928 - 12932
