2,4,6-三甲基苯胺合成路线 （共 254 条）
反应条件
C34H39N3O4Pd; sodium t-butanolate in 1,4-dioxane
T=100°C; Buchwald-Hartwig Coupling; 0.166667 h; Schlenk techniqueInert atmosphere;
参考文献
Krinsky, Jamin L.; Martinez, Alberto; Godard, Cyril; Castillon, Sergio; Claver, Carmen
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 2-3 p. 460 - 474
反应条件
tris(dibenzylideneacetone)dipalladium (0); di-tert-butylneopentylphosphonium tetrafluoroborate; sodium t-butanolate in toluene
T=50°C; Hartwig-Buchwald amination;
参考文献
Hill, Lensey L.; Moore, Lucas R.; Huang, Rongeai; Craciun, Raluca; Vincent, Andrew J.; Dixon, David A.; Chou, Joe; Woltermann, Christopher J.; Shaughnessy, Kevin H.
Journal of Organic Chemistry, 2006 , vol. 71, # 14 p. 5117 - 5125
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=82°C; 15 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias
Tetrahedron Letters, 1996 , vol. 37, # 33 p. 5861 - 5864
反应条件
diphosphorous tetraiodide in tetrachloromethane; dichloromethane
Heating;
参考文献
Suzuki, Hitomi; Tsuji, Junko; Sato, Naofumi; Osuka, Atsuhiro
Chemistry Letters, 1983 , p. 449 - 452
参考文献
Angelino, S. A. G. F.; Buurman, D. J.; Plas, H. C. van der; Mueller, F.
Recueil: Journal of the Royal Netherlands Chemical Society, 1983 , vol. 102, # 6 p. 331 - 336
反应条件
in toluene
byproducts: HCl; at -78°C for 1 h, allowed to warm to room temp. refluxed until dissolution of ppt.; solvent removed under vac., recrystn. from toluene/hexane or by very short-path distn. or sublimation under high vac.;
参考文献
Morse, Joseph G.; Glanville, W. Kent
Inorganic Chemistry, 1984 , vol. 23, p. 11 - 13
反应条件
in toluene
byproducts: HCl; at -78°C for 1 h, warm to room temp. refluxed for 1 week; solvent removed under vac., recrystn. from toluene/hexane or by very short-path distn. or sublimation under high vac., elem. anal.;
参考文献
Morse, Joseph G.; Glanville, W. Kent
Inorganic Chemistry, 1984 , vol. 23, p. 11 - 13
反应条件
in toluene
byproducts: 1,8-bis(dimethylamino)naphthalene hydrochloride; at -78°C under vac., allowed to warm with stirring to room temp., 30 min, chilled to ice temp., filtered under vac., solid washed with condensed solvent, removed the solvent by distn. under vac.; solid is byproduct, solvent heated to 45°C under continuous pumping, oily solid washed with warm heptane, dissolved in toluene, recrystd. with heptane, sublimed under vac.;
参考文献
Morse, Joseph G.; Glanville, W. Kent
Inorganic Chemistry, 1984 , vol. 23, p. 11 - 13
反应条件
1: 85 percent / formic acid (90percent), acetic anhydride / 3 h / Heating
2: NaOH, zinc dust / H2O; ethanol / 1 h / Heating
3: 78 percent / ammonium acetate, potassium ferricyanide / H2O; tetrahydrofuran / 240 h / 45 °C
4: 75 percent / ascorbic acid / H2O; methanol
View Scheme
参考文献
Goldstein, Stephen L.; McNelis, Edward
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1613 - 1620
反应条件
potassium iodide
T=140°C; 1 h;
参考文献
Paulsen, Andreas L.; Madsen, Robert
Heterocycles, 2004 , vol. 63, # 9 p. 2051 - 2056
