N,N-二乙基氯甲酰胺合成路线 （共 193 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 87 percent / hexane; tetrahydrofuran / 36 h / Heating
2.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 86 percent / iodine / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: 87 percent / hexane; tetrahydrofuran / 36 h / Heating
2.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 64 percent / 1,2-dibromoethane / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: NaH / tetrahydrofuran / 2 h / 20 °C
1.2: 91 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 84 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: NaH / tetrahydrofuran / 2 h / 20 °C
1.2: 91 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 71 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: pyridine / 48 h / 100 °C
2.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 1 h / -78 °C
2.2: 0.5 h / -78 - 20 °C
View Scheme
参考文献
Brown, Neil; Buszek, Keith R.
Tetrahedron Letters, 2012 , vol. 53, # 31 p. 4022 - 4025
反应条件
1.1: NaH / tetrahydrofuran / 2 h / 20 °C
1.2: 91 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 92 percent / hexachloroethane / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: NaH / tetrahydrofuran / 20 °C
1.2: 95 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 74 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C
1.2: 8 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 0.5 h / -78 °C
View Scheme
参考文献
The Florida State University Research Foundation, Inc.; Alabugin, Igor; Byers, Philip M.
Patent: US2013/109855 A1, 2013 ;
反应条件
1.1: NaH / tetrahydrofuran / 20 °C
1.2: 95 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 60 percent / 1,2-dibromoethane / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
反应条件
1.1: NaH / tetrahydrofuran / 20 °C
1.2: 95 percent / tetrahydrofuran / 8 h / 20 °C
2.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 70 percent / hexachloroethane / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Fernandez, Yolanda; Fananas, Francisco J.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6548 - 6551
