1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
T=20°C; 0.166667 h;
2: With triethylamine in dichloromethane
T=20°C; 15 h;
1: 3-thiophene-carboxylic acid With HATU in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: 3-iodo-4-methylphenylamine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/10995 A1, 2004 ;
Location in patent: Page/Page column 32 ;
WO 2004/010995 A1
