反应条件
1: 91 percent / 12N HCl / ethanol / 24 h / Heating 2: LiAlH4, (2R,3S)-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-butanol / tetrahydrofuran; toluene / 16 h / -70 °C 3: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C 4: 1) ClCO2CH2CCl3, Et3N, HCl 2) Zn-dust, 2.5percent formic acid / 1) toluene, 30 min, 25 deg C 2) DMF View Scheme
参考文献
Deeter, Jack; Frazier, Jeff; Staten, Gilbert; Staszak, Mike; Weigel, Leland
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 7101 - 7104
