4-硝基-3-(三氟甲基)苯酚合成路线 （共 12 条）
反应条件
tert.-butylhydroperoxide; potassium tert-butylate in ammonia T=-33°C;
参考文献
Journal of Organic Chemistry, , vol. 63, # 13 p. 4199 - 4208
反应条件
nitric acid in dichloromethane T=0°C;
参考文献
Tetrahedron Letters, , vol. 45, # 26 p. 5131 - 5133
反应条件
sulfuric acid; nitric acid T=0 - 10°C; Erwaermen des Reaktionsprodukts mit 20 prozentig. wss. NaOH auf dem Dampfbad;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 39, p. 298,306, 307
参考文献
Bulletin des Societes Chimiques Belges, , vol. 39, p. 298,306, 307
反应条件
1: K2CO3 / acetone / Heating 2: FeCl3; N2H4*H2O / methanol / Heating View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; GAJERA, Jitendra Maganbhai; NARAYANA, Lakshminarayana; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2012/110860 A1, 2012 ;
WO 2012/110860 A1
反应条件
potassium carbonate in acetone Reflux;
参考文献
Mao, Jialin; Yuan, Hai; Wang, Yuehong; Wan, Baojie; Pak, Dennis; He, Rong; Franzblau, Scott G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1263 - 1268
反应条件
1: (i) NaOH, (ii) /BRN= 1731042/ 2: (i) SOCl2, (ii) NH3, dioxane 3: (i) NaH, DMF, (ii) H2O View Scheme
参考文献
Bayles,R. et al.
Synthesis, 1977 , p. 31 - 33
反应条件
10 palladium on activated charcoal P=760.051 Torr;
参考文献
Boros, Eric E.; Kaldor, Istvan; Turnbull, Philip S.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 733 - 736
反应条件
1: With potassium carbonate in acetone 8 h; Heating / reflux; 2: With sodium hydroxide in 1,4-dioxane; water T=20°C; 3: With hydrogenchloride in 1,4-dioxane; water
参考文献
California Pacific Medical Center
Patent: US6350756 B1, 2002 ;
Location in patent: Page column 52 ;
反应条件
(i) NaOH, (ii) /BRN= 1731042/; Multistep reaction;
参考文献
Bayles,R. et al.
Synthesis, 1977 , p. 31 - 33
