反应条件
1: Fmoc-Gly Wang resin With piperidine in N,N-dimethyl-formamide
T=20°C;
2: 2-Bromobenzoic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 2 h;
3: With tri-iso-propylsilane; trifluoroacetic acid
T=20°C; 1 h;
参考文献
Burdick, Daniel J.; Paris, Ken; Weese, Kenneth; Stanley, Mark; Beresini, Maureen; Clark, Kevin; McDowell, Robert S.; Marsters Jr., James C.; Gadek, Thomas R.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1015 - 1018