反应条件
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere
2: SnCl2·2H2O / ethylene glycol dimethyl ether / 0 - 20 °C / Molecular sieve; Inert atmosphere
3: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 20 °C
View Scheme
参考文献
Granchi, Carlotta; Roy, Sarabindu; Giacomelli, Chiara; MacChia, Marco; Tuccinardi, Tiziano; Martinelli, Adriano; Lanza, Mario; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Funel, Nicola; Leon, Leticia G.; Giovannetti, Elisa; Peters, Godefridus J.; Palchaudhuri, Rahul; Calvaresi, Emilia C.; Hergenrother, Paul J.; Minutolo, Filippo
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1599 - 1612