反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere 1.2: 5 h / 23 °C 2.1: hydrazine hydrate; anhydrous iron chloride / methanol / 90 °C 3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine / 48 h / 23 °C 4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 23 °C 4.2: pH ~ 8 View Scheme
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; THE BROAD INSTITUTE, INC.; TSAI, Li-Huei; GUAN, Ji-Song; HAGGARTY, Stephen, J.; HOLSON, Edward; WAGNER, Florence; GRAEFF, Johannes
Patent: WO2011/53876 A1, 2011 ;
