反应条件
1.1: 62 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C
2.1: H2 / Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr
3.1: 46.8 g / imidazole / dimethylformamide / 15 h / 0 - 20 °C
4.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C
4.2: dimethylformamide / 0 - 20 °C
4.3: 0.478 g / aq. CH3SO3H / methanol / 0.5 h / 20 °C
View Scheme
参考文献
Rybczynski, Philip J.; Zeck, Roxanne E.; Dudash Jr., Joseph; Combs, Donald W.; Burris, Thomas P.; Yang, Maria; Osborne, Melville C.; Chen, Xiaoli; Demarest, Keith T.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 196 - 209