4-环己烯-1,2-二羧酸合成路线 （共 12 条）
反应条件
1.1: palladium; hydrogen / methanol / 30 - 35 °C 2.1: ethanol / 30 h / 35 - 75 °C 2.2: 1 h View Scheme
参考文献
LEE PHARMA LIMITED; ALLA, Venkat Reddy; ALLA, Raghu Mitra; DUBEY, Ajay Kumar; REDDY, P., Ramakrishna
Patent: WO2014/102808 A1, 2014 ;
反应条件
1: (CF3CO)2O 2: methanol View Scheme
参考文献
Schneider, Manfred; Engel, Norbert; Hoenicke, Petra; Heinemann, Gerd; Goerisch, Helmut
Angewandte Chemie, 1984 , vol. 96, # 1 p. 55 - 56
反应条件
1: (CF3CO)2O 2: methanol 3: t1/2, various of pH View Scheme
参考文献
Schneider, Manfred; Engel, Norbert; Hoenicke, Petra; Heinemann, Gerd; Goerisch, Helmut
Angewandte Chemie, 1984 , vol. 96, # 1 p. 55 - 56
反应条件
Hydrogenation; cis-Δ4-tetrahydrophthalic acid;
参考文献
Diels; Alder
Justus Liebigs Annalen der Chemie, 1928 , vol. 460, p. 98
Justus Liebigs Annalen der Chemie, 1930 , vol. 478, p. 141
反应条件
1.1: palladium; hydrogen / methanol / 30 - 35 °C 2.1: ethanol / 30 h / 35 - 75 °C 2.2: 1 h 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 65 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shri Prakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/121440 A1, 2013 ;
反应条件
acetic anhydride T=60 - 70°C;
参考文献
Bernath, Gabor; Stajer, Geza; Szabo, Angela E.; Fueloep, Ferenc; Sohar, Pal
Tetrahedron, 1985 , vol. 41, # 7 p. 1353 - 1366
反应条件
1: (CF3CO)2O 2: methanol 3: t1/2, various of pH View Scheme
参考文献
Schneider, Manfred; Engel, Norbert; Hoenicke, Petra; Heinemann, Gerd; Goerisch, Helmut
Angewandte Chemie, 1984 , vol. 96, # 1 p. 55 - 56
反应条件
1: acetyl chloride 2: palladium; chloroform / Hydrogenation View Scheme
参考文献
Nasarow; Kutscherow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1954 , p. 329,333; engl. Ausg. S. 269, 272
反应条件
potassium permanganate; water; sodium carbonate
参考文献
Alder; Schumacher
Justus Liebigs Annalen der Chemie, 1949 , vol. 564, p. 96,108
Synth. org. Verb., 1959 , vol. 1, p. 28
反应条件
palladium on activated charcoal Hydrogenation;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shri Prakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/121440 A1, 2013 ;
Location in patent: Page/Page column 26 ;
