aluminium trichloride in dichloromethane T=20°C; Friedel-Crafts acylation; 2 h; Title compound not separated from byproducts;

1: 3-bromo-4-hexylthiophene; n-heptanoic acid chloride With aluminium trichloride in dichloromethane T=20°C; Friedel-Crafts acylation; 2 h; 2: mercapto acetic acid ethylester With 18-crown-6 ether; potassium carbonate in N,N-dimethyl-formamide T=60 - 70°C; 3: With lithium hydroxide; tetra-(n-butyl)ammonium iodide in tetrahydrofuran; methanol; water 3 h; Heating;

1: 3-bromo-4-hexylthiophene; n-heptanoic acid chloride With aluminium trichloride in dichloromethane T=20°C; Friedel-Crafts acylation; 2 h; 2: mercapto acetic acid ethylester With 18-crown-6 ether; potassium carbonate in N,N-dimethyl-formamide T=60 - 70°C; Title compound not separated from byproducts;

1: 83 percent / n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C 2: AlCl3 / CH2Cl2 / 2 h / 20 °C View Scheme

1: acetic acid; bromine / 20 - 70 °C 2: 83 percent / n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C 3: AlCl3 / CH2Cl2 / 2 h / 20 °C View Scheme