1: ethyl acetoacetate With potassium tert-butylate in tetrahydrofuran; tert-butyl alcohol T=0 - 15°C; 0.666667 h; 2: 1-(chloromethyl)-4-fluorobenzene in tetrahydrofuran; tert-butyl alcohol T=70°C; 20 h;

1: ethyl acetoacetate With potassium tert-butylate in tetrahydrofuran; tert-butyl alcohol T=0°C; 0.5 h; Inert atmosphere; 2: 4-bromomethyl-fluorobenzene in tetrahydrofuran; tert-butyl alcohol T=0 - 70°C; Inert atmosphere;

in ethanol 2 h; Heating;

1: 5percent aq. NaOH / 1.) ambient temperature, 4 h, 2.) reflux, 6 h 2: 58 percent / diethyl ether / 2 h / Heating 3: H2SO4 / acetic acid / 1.5 h / 70 °C 4: 20percent HCl / 1 h / Heating View Scheme