3-(6-甲基吡啶-2-基乙炔)-2-环己酮合成路线 （共 3 条）
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride in DMF (N,N-dimethyl-formamide)
T=55°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2005/30723 A1, 2005 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: 23.9 g / sodium hydroxide / benzene / 1 h / Heating
2: 75 percent / triethylamine; copper(I) iodide / bis(triphenylphosphine)palladium(II) dichloride / dimethylformamide / 1 h / 55 °C
View Scheme
参考文献
Hintermann, Samuel; Vranesic, Ivo; Allgeier, Hans; Bruelisauer, Armin; Hoyer, Daniel; Lemaire, Michel; Moenius, Thomas; Urwyler, Stephan; Whitebread, Steven; Gasparini, Fabrizio; Auberson, Yves P.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 903 - 914
反应条件
1: triethylamine; copper(I) iodide / bis(triphenylphosphine)palladium(II) dichloride / 2 h / 55 °C
2: 23.9 g / sodium hydroxide / benzene / 1 h / Heating
3: 75 percent / triethylamine; copper(I) iodide / bis(triphenylphosphine)palladium(II) dichloride / dimethylformamide / 1 h / 55 °C
View Scheme
参考文献
Hintermann, Samuel; Vranesic, Ivo; Allgeier, Hans; Bruelisauer, Armin; Hoyer, Daniel; Lemaire, Michel; Moenius, Thomas; Urwyler, Stephan; Whitebread, Steven; Gasparini, Fabrizio; Auberson, Yves P.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 903 - 914
