1: 2-amino-3-(3-bromo-phenyl)-N-((2R)-hydroxy-(1R)-methyl-2-phenyl-ethyl)-N-methyl-propionamide With sodium hydroxide in water 2 h; Heating / reflux; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in 1,4-dioxane T=0 - 20°C;