1-(2-甲基噻唑-4-甲基)-哌嗪盐酸盐合成路线 (共 2 条)
反应条件
1: in methanol 3 h; 2: With potassium hydroxide in methanol T=20°C;
参考文献
Merck Sharp and Dohme Limited; DIRAT, Olivier; ELLIOTT, Jason, Matthew
Patent: WO2007/3965 A1, 2007 ;
Location in patent: Page/Page column 37 ;
WO 2007/003965 A1
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 2 h;
参考文献
WO2009/1021 A1, ;
Page/Page column 30-31 ;
WO 2009/001021 A1