4-(4-氧代哌啶-1-基)哌啶-1-羧酸苄酯合成路线 （共 5 条）
反应条件
hydrogenchloride
T=0 - 20°C;
参考文献
Semetey, Vincent; Moustakas, Demetri; Whitesides, George M.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 4 p. 588 - 591
反应条件
1: With hydrogenchloride; isopropyl alcohol in acetone
Heating / reflux;
2: With sodium hydroxide; water
参考文献
ASTRAZENECA AB
Patent: US2007/287695 A1, 2007 ;
Location in patent: Page/Page column 45-46 ;
US 20070287695 A1
反应条件
1: 90 percent / Na2CO3 / dioxane; H2O / 2 h / 20 °C
2: 56 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C
3: 72 percent / aq. HCl / 0 - 20 °C
View Scheme
参考文献
Semetey, Vincent; Moustakas, Demetri; Whitesides, George M.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 4 p. 588 - 591
反应条件
1: 56 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C
2: 72 percent / aq. HCl / 0 - 20 °C
View Scheme
参考文献
Semetey, Vincent; Moustakas, Demetri; Whitesides, George M.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 4 p. 588 - 591
反应条件
1: 90 percent / Na2CO3 / dioxane; H2O / 2 h / 20 °C
2: 56 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C
3: 72 percent / aq. HCl / 0 - 20 °C
View Scheme
参考文献
Semetey, Vincent; Moustakas, Demetri; Whitesides, George M.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 4 p. 588 - 591
