lithium hydroxide in methanol; water T=65°C; 0.75 h;

1: 85 percent / K2CO3 / dimethylformamide 2: N-bromosuccinimide, benzoyl peroxide / CCl4 / 2 h / Heating 3: 50 percent / NaH / dimethylformamide / 1 h / 0 °C 4: 82 percent / LiOH*H2O / methanol; H2O / 0.75 h / 65 °C View Scheme

1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 2 h / Heating 2: 50 percent / NaH / dimethylformamide / 1 h / 0 °C 3: 82 percent / LiOH*H2O / methanol; H2O / 0.75 h / 65 °C View Scheme