Fmoc-L-4-羟基脯氨酸合成路线 （共 6 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water; toluene
参考文献
ISIS Pharmaceuticals, Inc.
Patent: US6828427 B1, 2004 ;
Title/Abstract Full Text Show Details
ISIS Pharmaceuticals, Inc.
Patent: US6184389 B2, 2001 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water Yield given;
参考文献
Tetrahedron Letters, , vol. 35, # 51 p. 9509 - 9512
反应条件
1: CH2Cl2 / 3.5 h / Ambient temperature 2: MeOH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 30, # 2 p. 183 - 186
反应条件
1: CH2Cl2 / 3.5 h / Ambient temperature 2: MeOH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 30, # 2 p. 183 - 186
反应条件
hydrogenchloride 4 h; Heating; Yield given;
参考文献
Tran, Thanh Thu; Patino, Nadia; Condom, Roger; Frogier, Tea; Guedj, Roger
Journal of Fluorine Chemistry, 1997 , vol. 82, # 2 p. 125 - 130
反应条件
1: pyridine; Fluolead; hydrogen fluoride / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere
2: ammonia / dichloromethane; water / 20 °C / Inert atmosphere
3: diethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Singh, Rajendra P.; Umemoto, Teruo
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3113 - 3121
