(-)-2-氰-6-苯基恶唑哌啶合成路线 （共 7 条）
反应条件
1: 1.) LDA / 1.) hexane, THF, -78 deg C, 45 min, 2.) -78 deg C, 2.5 h 2: 82 percent / sodium borohydride / ethanol / 4 h / Heating 3: H2 / Pd/C / methanol View Scheme
参考文献
McIntosh; Matassa
Journal of Organic Chemistry, 1988 , vol. 53, # 19 p. 4452 - 4457
反应条件
1: (2R)-2-hydroxy-2-phenylethylamine; glutardialdehyde With citric acid in water
T=0°C; 0.5 h;
2: potassium cyanide in dichloromethane; water
T=0 - 20°C; 3.5 h;
3: With sodium hydroxide; zinc dibromide
more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/34133 A1, 2009 ;
Location in patent: Page/Page column 12-13 ;
WO 2009/034133 A1
反应条件
1: H2O / 1 h / pH 3.0
2: H2O / 72 h / Ambient temperature; pH 3.0
View Scheme
参考文献
Guerrier; Royer; Grierson; Husson
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7754 - 7755
反应条件
in water
72 h; Ambient temperaturepH 3.0; Yield given;
参考文献
Guerrier; Royer; Grierson; Husson
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7754 - 7755
参考文献
Royer, Jacques; Husson, Henri-Phillipe
Heterocycles, 1993 , vol. 36, # 7 p. 1493 - 1496
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 2.) 3 h; Yield given;
参考文献
Guerrier; Royer; Grierson; Husson
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7754 - 7755
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 2.) 3 h
2: 1.) AgBF4, 2.) Zn(BH4)2 / 1.) THF, -60 deg C, 30 min
View Scheme
参考文献
Guerrier; Royer; Grierson; Husson
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7754 - 7755
