sodium hydride in dichloromethane; N,N-dimethyl-formamide Ambient temperature;

1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr 2: 83 percent / 2,6-lutidine / benzene 3: 80 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature View Scheme

1: 83 percent / 2,6-lutidine / benzene 2: 80 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature View Scheme

sodium hydroxide; water in pyridine; methanol 24 h; Heating;