4-((三甲基甲硅烷基)乙炔)苯酚合成路线 （共 13 条）
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 5.5 h / 20 °C 2: potassium fluoride / methanol / 32 h / 20 °C 3: tetrakis(triphenylphosphine) palladium(0); hydrogenchloride / tetrahydrofuran; water / 48 h / 45 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao
Organic Letters, 2014 , vol. 16, # 3 p. 948 - 951
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / |Inert atmosphere; |Cooling with ice 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Kwon, Jinsun; Kondaji, Gajulapati; Song, Sumi; Kim, Chorong; Lee, Kyeong; Kim, Won-Ki; Choi, Yongseok
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1247 - 1249
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 5.5 h / 20 °C 2: potassium fluoride / methanol / 32 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 16, # 3 p. 948 - 951
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: potassium fluoride / methanol / 46 h / 20 °C View Scheme
参考文献
Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao
Organic Letters, 2014 , vol. 16, # 3 p. 948 - 951
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: potassium fluoride / methanol / 46 h / 20 °C 3: tetrakis(triphenylphosphine) palladium(0); hydrogenchloride / tetrahydrofuran; water / 55 h / 45 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao
Organic Letters, 2014 , vol. 16, # 3 p. 948 - 951
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 5.5 h;
参考文献
Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao
Organic Letters, 2014 , vol. 16, # 3 p. 948 - 951
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
T=80°C; 3 h; Inert atmosphere;
参考文献
Kwon, Jinsun; Kondaji, Gajulapati; Song, Sumi; Kim, Chorong; Lee, Kyeong; Kim, Won-Ki; Choi, Yongseok
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1247 - 1249
反应条件
lithium hydroxide hydrate; water in tetrahydrofuran; methanol
T=0°C; 0.5 h; Inert atmosphere;
参考文献
Ladouceur, Sebastien; Soliman, Ahmed M.; Zysman-Colman, Eli
Synthesis, 2011 , # 22 art. no. M79111SS, p. 3604 - 3611
反应条件
copper(l) iodide; (PPh3)2; triethylamine; palladium dichloride
1 h; Ambient temperature;
参考文献
Krause; Ligneau; Stark; Garbarg; Schwartz; Schunack
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4171 - 4176
参考文献
Centre International de Recherches Dermatologiques
Patent: US6150413 A1, 2000 ;
