2-[2-[(3S)-3-[3-[(1E)-2-(7-氯喹啉-2-基)乙烯基]苯基]-3-氯丙基]苯基]-2-丙醇合成路线 （共 2 条）
反应条件
1: 1-(mercaptomethyl)-cyclopropaneacetic acid With sodium hydride in N,N-dimethyl-formamide T=-5°C; 1 h; 2: 2-[2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]phenyl]-2-propanol in N,N-dimethyl-formamide T=-5 - 0°C; 13 h; 3: N,N-dicyclohexylamine in ethyl acetate T=20 - 22°C; 1.75 h;
参考文献
Matrix Laboratories Ltd
Patent: EP1812394 B1, 2011 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: 1-(mercaptomethyl)-cyclopropaneacetic acid With caesium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: 2-[2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]phenyl]-2-propanol in N,N-dimethyl-formamide T=30 - 55°C; 2 - 3 h; Product distribution / selectivity;
参考文献
Gorantla, Seeta Ramanjaneyulu; Bandari, Mohan; Indukuri, Venkata Sunil Kumar; Simhadri, Srinivas; Ketavarapu, Narasimha Rao; Jammulaveera, Venkata Krishna Kishore; Mohammed, Yaseen
Patent: US2011/92708 A1, 2011 ;
Location in patent: Page/Page column 5-6 ;
