3-溴-1-甲基磺酰基-1H-吡咯并[2,3-B]吡啶合成路线 （共 6 条）
反应条件
N-bromosuccinmide in tetrahydrofuran
参考文献
Huang, Shenlin; Li, Ronghua; Connolly, Peter J.; Emanuel, Stuart; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4818 - 4821
反应条件
potassium carbonate in acetone
参考文献
Ibrahim, Prabha N.; Bremer, Ryan; Gillette, Sam; Cho, Hanna; Nespi, Marika; Mamo, Shumeye; Zhang, Chao; Artis, Dean R.; Lee, Byunghun; Zuckerman, Rebecca
Patent: US2006/100218 A1, 2006 ;
Location in patent: Page/Page column 52 ;
US 20060100218 A1
反应条件
1: 90 percent / Et3N / tetrahydrofuran 2: 86 percent / N-bromosuccinimide / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4818 - 4821
反应条件
1: 90 percent / Et3N / tetrahydrofuran 2: 86 percent / N-bromosuccinimide / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4818 - 4821
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in tetrahydrofuran
参考文献
Huang, Shenlin; Li, Ronghua; Connolly, Peter J.; Emanuel, Stuart; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4818 - 4821
反应条件
sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water; N,N-dimethyl-formamide T=120°C; Suzuki Coupling; 0.25 h; Microwave on 50 watts;
参考文献
SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 151-152 ;
WO 2008/005457 A2
