sodium hydroxide 1 h; Ambient temperature;

1: pyridine / 1) 2-3 deg C, 4 h, 2) room temperature, 18 h 2: LiBr / dimethylformamide / 90 °C 3: 1) Mg / 1) ether, 2) -70 deg C, 0,4 h 4: 76 percent / 1 N NaOH / 1 h / Ambient temperature View Scheme

1: LiBr / dimethylformamide / 90 °C 2: 1) Mg / 1) ether, 2) -70 deg C, 0,4 h 3: 76 percent / 1 N NaOH / 1 h / Ambient temperature View Scheme

1: 1) Mg / 1) ether, 2) -70 deg C, 0,4 h 2: 76 percent / 1 N NaOH / 1 h / Ambient temperature View Scheme

in diethyl ether T=0°C; 12 h;