2,5-二(2-噻吩基)呋喃合成路线 （共 8 条）
反应条件
potassium hydroxide in water; dimethyl sulfoxide
T=130°C; 1 h; Microwave irradiation;
参考文献
Klukas, Fabian; Grunwald, Alexander; Menschel, Franziska; Mueller, Thomas J. J.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 672 - 679
反应条件
[BMIm][HSO4]
T=150°C; Paal-Knorr furan synthesis; 3 h; Sealed tubeNeat (no solvent);
参考文献
Wang, Gangqiang; Guan, Zhi; Tang, Rongchang; He, Yanhong
Synthetic Communications, 2010 , vol. 40, # 3 p. 370 - 377
反应条件
copper(l) iodide; 1,10-phenanthroline; water; potassium hydroxide in dimethyl sulfoxide
T=80°C; 6 h; regioselective reaction;
参考文献
Jiang, Huanfeng; Zeng, Wei; Li, Yibiao; Wu, Wanqing; Huang, Liangbing; Fu, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5179 - 5183
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in diethyl ether
1.) -30 deg C, 0.5 h; 2.) RT, 2.5 h;
参考文献
Carpita, Adriano; Rossi, Renzo; Veracini, Carlo Alberto
Tetrahedron, 1985 , vol. 41, # 10 p. 1919 - 1930
反应条件
1: potassium fluoride / dimethyl sulfoxide / 16 h / 20 °C
2: potassium hydroxide / dimethyl sulfoxide; water / 1 h / 130 °C / |Microwave irradiation
View Scheme
参考文献
Klukas, Fabian; Grunwald, Alexander; Menschel, Franziska; Mueller, Thomas J. J.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 672 - 679
反应条件
n-butyllithium; zinc(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride
1.) hexane, THF, 0 deg C, 3.5 h; 2.) hexane, THF, a.) 0 deg C, 4.5 h; b.) RT, 15 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Carpita, Adriano; Rossi, Renzo; Veracini, Carlo Alberto
Tetrahedron, 1985 , vol. 41, # 10 p. 1919 - 1930
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in diethyl ether
1.) -30 deg C; 2.) -10 deg C, 2.5 h; 3.) RT, 1 h;
参考文献
Carpita, Adriano; Rossi, Renzo; Veracini, Carlo Alberto
Tetrahedron, 1985 , vol. 41, # 10 p. 1919 - 1930
反应条件
1: 1.) LDA, 2.) CuCl2 / 1.) hexane, THF, -78 deg C, 30 min, 2.) DMF, hexane, THF, -40 deg C, 40 min
2: 87 percent / acetic anhydride, HCl gas / 2 h / Ambient temperature
View Scheme
参考文献
Kagan, Jacques; Arora, Sudershan K.
Heterocycles, 1983 , vol. 20, # 10 p. 1941 - 1943
