1: 35 percent / 0.2 N NaOH / methanol / 20 °C 2: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr 3: 64 percent / 2,6-lutidine / benzene 4: 78 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature View Scheme

1: 35 percent / 0.2 N NaOH / methanol / 20 °C 2: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr 3: 64 percent / 2,6-lutidine / benzene 4: 78 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature 5: 90 percent / water, NaOH / pyridine; methanol / 24 h / Heating View Scheme

1: 35 percent / 0.2 N NaOH / methanol / 20 °C 2: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr 3: 64 percent / 2,6-lutidine / benzene 4: 78 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature 5: 90 percent / water, NaOH / pyridine; methanol / 24 h / Heating 6: 48 percent / BBr3 / CH2Cl2 / 24 h / -35 °C View Scheme

1: 46 percent / NaOAc 2: 76 percent / NH3 / methanol View Scheme

1: DIEA / dimethylformamide / 18 h / 20 °C 2: CH2Cl2 / 18 h / 20 °C 3: H2 / Pd / tetrahydrofuran; methanol / 72 h / 20 °C / 760 Torr 4: toluene / Heating 5: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C View Scheme