4-氯-2-(1,1-二甲基乙基)-5-羟基-3(2H)-吡嗪酮合成路线 （共 3 条）
反应条件
potassium hydroxide in ethylene glycol
T=130°C; 5 h;
参考文献
Cao, Song; Qian, Xuhong; Song, Gonghua; Chai, Bing; Jiang, Zhisheng
Journal of Agricultural and Food Chemistry, 2003 , vol. 51, # 1 p. 152 - 155
反应条件
1: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 20 h / 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 22 h / 20 °C
4: TEAHCO3; tetraethyl ammonium [18]F-fluoride / acetonitrile / 0.17 h / 90 °C
View Scheme
参考文献
LANTHEUS MEDICAL IMAGING, INC.; CESATI, Richard, R.; CHEESMAN, Edward, H.; LAZEWATSKY, Joel; RADEKE, Heike, S.; CASTNER, James, F.; MONGEAU, Enrico; ZDANKIEWICZ, Dianne, D.; SIEGLER, Robert, Wilburn; DEVINE, Marybeth
Patent: WO2011/97649 A2, 2011 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Purohit, Ajay; Radeke, Heike; Azure, Michael; Hanson, Kelley; Benetti, Richard; Su, Fran; Yalamanchili, Padmaja; Yu, Ming; Hayes, Megan; Guaraldi, Mary; Kagan, Mikhail; Robinson, Simon; Casebier, David
Journal of Medicinal Chemistry, 2008 , vol. 51, # 10 p. 2954 - 2970
