N-(4-溴-2-硝基苯基)乙酰胺合成路线 （共 23 条）
反应条件
1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 8 h / 20 - 110 °C / |Inert atmosphere 2: potassium hydroxide; water / ethanol / 12 h / 90 °C 3: palladium on activated charcoal; hydrogen / tetrahydrofuran; ethanol / 4 h / 775.74 Torr View Scheme
参考文献
Ullah, Nisar
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 2 p. 281 - 291
反应条件
potassium hydroxide in ethanol T=80°C; 12 h;
参考文献
Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 29, # 2 p. 281 - 291
反应条件
1.1: hydrogenchloride / water / Reflux 2.1: diethyl ether / 1 h / 100 °C 2.2: 3 h / 50 - 110 °C 2.3: 3 h / 50 - 110 °C View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
1: 3N KOH / 24 h / Heating 2: 1.) sodium nitrite, 5N HCl; 2.) aq. KI / 1.) 0-10 deg C; 2.) RT, 30 min 3: 69 percent / SnCl2, conc. HCl / ethanol / 0.25 h / 50 - 60 °C 4: 72 percent / pyridine / 3 h / 0-10 deg C 5: CuI, Et3N / Pd(PPh3)2Cl2 / 60 °C 6: NaOEt / ethanol / Heating View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Iwashita, Shigeki; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 5 p. 1823 - 1828
反应条件
sulfuric acid; orthoarsenic acid
参考文献
Decker; Kaufmann
Journal fuer Praktische Chemie (Leipzig), 1911 , vol. <2> 84, p. 447
反应条件
potassium carbonate; C28H30Cl2N2O4Pd2S4 in toluene T=110°C; Suzuki Coupling; 10 h;
参考文献
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Patent: WO2005/92839 A1, 2005 ;
Location in patent: Page/Page column 5; 7-8 ;
反应条件
1: 3N KOH / 24 h / Heating 2: 1.) sodium nitrite, 5N HCl; 2.) aq. KI / 1.) 0-10 deg C; 2.) RT, 30 min 3: 69 percent / SnCl2, conc. HCl / ethanol / 0.25 h / 50 - 60 °C View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 35, # 5 p. 1823 - 1828
反应条件
hydrogenchloride; tin Behandlung des Reaktionsprodukts mit Natriumamalgam in waessrig-alkoh. Loesung;
参考文献
Huebner
Justus Liebigs Annalen der Chemie, 1881 , vol. 209, p. 358
反应条件
1: 3N KOH / 24 h / Heating 2: 1.) sodium nitrite, 5N HCl; 2.) aq. KI / 1.) 0-10 deg C; 2.) RT, 30 min View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 35, # 5 p. 1823 - 1828
反应条件
1: aqueous hydrochloric acid 2: aqueous hydrochloric acid; tin (II)-chloride View Scheme
参考文献
Ullah, Nisar
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 2 p. 281 - 291
