N-(2-氯-4-硝基苯基)乙酰胺合成路线 （共 19 条）
反应条件
1: aqueous sulfuric acid 2: aqueous H2SO4 / Diazotization.Behandlung der Diazoniumsalz-Loesung mit Kaliumthiocyanat und FeCl3 3: ethanolic (NH4)2 S View Scheme
参考文献
Challenger; Higginbottom; Huntington
Journal of the Chemical Society, 1930 , p. 26,29, 31
反应条件
hydrogenchloride; SnCl2·2H2O in water T=20°C; 2 h;
参考文献
MERCK SHARP and DOHME CORP; ADDEX PHARMA S.A.; LIVERTON, Nigel; JONES, Philip; BOLEA, Christelle; CELANIRE, Sylvain; TANG, Lam; BOUDOU, Cedric; LEI, Zhiyu; LIU, Fuqing; LUO, Yunfu; DONG, Jingchao; SOLL, Richard
Patent: WO2013/60029 A1, 2013 ;
Location in patent: Paragraph 0113 ;
参考文献
Challenger; Higginbottom; Huntington
Journal of the Chemical Society, 1930 , p. 26,29, 31
反应条件
pyridine in dichloromethane
T=20°C;
参考文献
MERCK SHARP and DOHME CORP; ADDEX PHARMA S.A.; LIVERTON, Nigel; JONES, Philip; BOLEA, Christelle; CELANIRE, Sylvain; TANG, Lam; BOUDOU, Cedric; LEI, Zhiyu; LIU, Fuqing; LUO, Yunfu; DONG, Jingchao; SOLL, Richard
Patent: WO2013/60029 A1, 2013 ;
Location in patent: Paragraph 0112 ;
反应条件
MOA; water; nitric acid in chloroform
Nitration; 6 h; Heating;
参考文献
Sana, Sariah; Rajanna; Ali, Mir Moazzam; Saiprakash
Chemistry Letters, 2000 , # 1 p. 48 - 49
反应条件
Bi(NO3)3·5H2O in dichloromethane
T=23°C; regioselective reaction;
参考文献
Lu, Yang; Li, Yaming; Zhang, Rong; Jin, Kun; Duan, Chunying
Tetrahedron, 2013 , vol. 69, # 45 p. 9422 - 9427
反应条件
sodium periodate; sulfuric acid; sodium lauryl sulfate; acetic acid; sodium chloride in water
T=25°C; 2 h;
参考文献
Mahajan, Tanu; Kumar, Lalit; Dwivedi, K.; Agarwal, D. D.
Synthetic Communications, 2012 , vol. 42, # 24 p. 3655 - 3663,9
反应条件
p-trifluoromethylthiobenzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride in dichloromethane
20 h; Ambient temperature;
参考文献
Miyashita, Mitsutomo; Shiina, Isamu; Mukaiyama, Teruaki
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 1 p. 210 - 215
反应条件
hydrogenchloride; sodium chlorate in water; acetic acid
T=20°C; 20 h;
参考文献
Moon, Byung Seok; Choi, Han Young; Koh, Hun Yeong; Chi, Dae Yoon
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 2 p. 472 - 476
反应条件
nitric acid
T=-10°C;
参考文献
Lobry de Bruyn
Recueil des Travaux Chimiques des Pays-Bas, 1917 , vol. 36, p. 139
