hydrogen; palladium in methanol; water; acetic acid

1: N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 1 h; 2.) room temp, 1 h 2: 70 percent / TEA / dioxane / 20 h / Ambient temperature 3: 75 percent / H2 / Pd / acetic acid; methanol; H2O View Scheme

1: 70 percent / TEA / dioxane / 20 h / Ambient temperature 2: 75 percent / H2 / Pd / acetic acid; methanol; H2O View Scheme