6,7-二氟-2,3-二氢茚-1-酮合成路线 (共 2 条)
反应条件
1: (COCl)2; DMF / 18 h / 20 °C
2: AlCl3 / CH2Cl2 / 3.5 h / Heating
View Scheme
参考文献
Musso, David L.; Cochran, Felicia R.; Kelley, James L.; McLean, Ed W.; Selph, Jeffrey L.; Rigdon, Greg C.; Orr, G. Faye; Davis, Ronda G.; Cooper, Barrett R.; Styles, Virgil L.; Thompson, James B.; Hall, William R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 399 - 408
反应条件
aluminium trichloride in dichloromethane
Friedel-Crafts acylation; 3.5 h; Heating;
参考文献
Musso, David L.; Cochran, Felicia R.; Kelley, James L.; McLean, Ed W.; Selph, Jeffrey L.; Rigdon, Greg C.; Orr, G. Faye; Davis, Ronda G.; Cooper, Barrett R.; Styles, Virgil L.; Thompson, James B.; Hall, William R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 399 - 408