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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
88132-51-8
合成路线
（共 7 条）
1547162-72-0
→
反应条件
88132-51-8
反应条件
Oxone® in water; acetone T=20°C; 1 h; Cooling with ice;
参考文献
CELGENE CORPORATION; TRAVERSE, John, F.; FEIGELSON, Gregg, Brian; RUCHELMAN, Alexander, L.; LIU, Jihong; LIU, Hongfeng; MA, Chengjun; LIU, Danyang; ZHANG, Steven
Patent: WO2014/18866 A1, 2014 ;
Location in patent: Paragraph 00181; 00185 ;
52090-24-1
2-甲基-3,5二硝基苯甲酸甲酯
→
反应条件
88132-51-8
反应条件
1: 60 percent / HCO2NHEt3 / 5percent Pd/C / acetonitrile / Heating 2: 70 percent / 48percent HBF4, tert-butyl nitrite / ethanol / 0.5 h / 0 °C 3: Cu(NO3)2*3H2O, Cu2O, 0.1 N H2SO4 / 0.25 h View Scheme
参考文献
Cannon; Lee; Ilhan; Koons; Long
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 386 - 389
88132-48-3
甲基5-氨基-2-甲基-3-硝基苯甲酸酯
→
反应条件
88132-51-8
反应条件
1: 70 percent / 48percent HBF4, tert-butyl nitrite / ethanol / 0.5 h / 0 °C 2: Cu(NO3)2*3H2O, Cu2O, 0.1 N H2SO4 / 0.25 h View Scheme
参考文献
Cannon; Lee; Ilhan; Koons; Long
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 386 - 389
88132-50-7
→
反应条件
88132-51-8
反应条件
copper(I) oxide; sulfuric acid; copper(II) nitrate 0.25 h; Yield given;
参考文献
Cannon; Lee; Ilhan; Koons; Long
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 386 - 389
107650-20-4
2-甲基-3-硝基-5-溴苯甲酸
→
反应条件
88132-51-8
反应条件
1: thionyl chloride / |Reflux 2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / |Reflux; |Inert atmosphere 3: Oxone® / acetone; water / 1 h / 20 °C / |Cooling with ice View Scheme
参考文献
CELGENE CORPORATION; TRAVERSE, John, F.; FEIGELSON, Gregg, Brian; RUCHELMAN, Alexander, L.; LIU, Jihong; LIU, Hongfeng; MA, Chengjun; LIU, Danyang; ZHANG, Steven
Patent: WO2014/18866 A1, 2014 ;
1975-50-4
2-甲基-3-硝基苯甲酸
→
反应条件
88132-51-8
反应条件
1: sulfuric acid; 1,3-dibromo-5,5-dimethyl-hydantoin / 20 °C / |Cooling with ice 2: thionyl chloride / |Reflux 3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / |Reflux; |Inert atmosphere 4: Oxone® / acetone; water / 1 h / 20 °C / |Cooling with ice View Scheme
参考文献
CELGENE CORPORATION; TRAVERSE, John, F.; FEIGELSON, Gregg, Brian; RUCHELMAN, Alexander, L.; LIU, Jihong; LIU, Hongfeng; MA, Chengjun; LIU, Danyang; ZHANG, Steven
Patent: WO2014/18866 A1, 2014 ;
220514-28-3
2-甲基-3-硝基-5-溴苯甲酸甲酯
→
反应条件
88132-51-8
反应条件
1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / |Reflux; |Inert atmosphere 2: Oxone® / acetone; water / 1 h / 20 °C / |Cooling with ice View Scheme
参考文献
CELGENE CORPORATION; TRAVERSE, John, F.; FEIGELSON, Gregg, Brian; RUCHELMAN, Alexander, L.; LIU, Jihong; LIU, Hongfeng; MA, Chengjun; LIU, Danyang; ZHANG, Steven
Patent: WO2014/18866 A1, 2014 ;
