6-氟喹唑啉-2,4-二醇合成路线 （共 7 条）
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
反应条件
TBA2[WO4] in dimethyl sulfoxide T=119.84°C; P=15001.5 Torr; 48 h; Autoclave; Catalytic behavior; TimeTemperaturePressure;
参考文献
Kimura, Toshihiro; Sunaba, Hanako; Kamata, Keigo; Mizuno, Noritaka
Inorganic Chemistry, 2012 , vol. 51, # 23 p. 13001 - 13008
参考文献
Hoffmann-La Roche Inc.
Patent: US5688803 A1, 1997 ;
反应条件
water; sodium hydroxide T=20 - 100°C;
参考文献
Smits, Rogier A.; De Esch, Iwan J. P.; Zuiderveld, Obbe P.; Broeker, Joachim; Sansuk, Kamonchanok; Guaita, Elena; Coruzzi, Gabriella; Adami, Maristella; Haaksma, Eric; Leurs, Rob
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7855 - 7865
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1593 - 1597
反应条件
1: 70 percent / POCl3; N,N-dimethylaniline / 16 h / Heating 2: 95 percent / aq. NaOH / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300
反应条件
N,N-diethylaniline; trichlorophosphate 3 h; Reflux;
参考文献
Smits, Rogier A.; De Esch, Iwan J. P.; Zuiderveld, Obbe P.; Broeker, Joachim; Sansuk, Kamonchanok; Guaita, Elena; Coruzzi, Gabriella; Adami, Maristella; Haaksma, Eric; Leurs, Rob
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7855 - 7865
