1: 35 percent / methanol; pyridine / 0.33 h / Ambient temperature 2: 85 percent / AcONH4, 15percent aq. TiCl3 / tetrahydrofuran; H2O / 1 h / 60 °C 3: p-toluene sulfonic acid / 6 h / Ambient temperature 4: tetramethylguanidine 5: LiAlH(Ot-Bu)3 / tetrahydrofuran / 1.) 18 h, RT 2.) 3 h, 60 deg C 6: 70 percent / NH4OAc, 15percent aq. TiCl3 / tetrahydrofuran / Ambient temperature 7: NaBH4 / methanol / 2 h / Ambient temperature 8: 5percent HCl / tetrahydrofuran / 25 °C View Scheme

1: 35 percent / methanol; pyridine / 0.33 h / Ambient temperature 2: 85 percent / AcONH4, 15percent aq. TiCl3 / tetrahydrofuran; H2O / 1 h / 60 °C 3: p-toluene sulfonic acid / 6 h / Ambient temperature 4: tetramethylguanidine 5: LiAlH(Ot-Bu)3 / tetrahydrofuran / 1.) 18 h, RT 2.) 3 h, 60 deg C 6: 70 percent / NH4OAc, 15percent aq. TiCl3 / tetrahydrofuran / Ambient temperature 7: NaBH4 / methanol / 2 h / Ambient temperature View Scheme

1: p-toluene sulfonic acid / 6 h / Ambient temperature 2: tetramethylguanidine 3: 75.6 percent / LiAlH(Ot-Bu)3 / tetrahydrofuran / 1.) 18 h, RT 2.) 3 h, 60 deg C 4: Et3N, PhNCO / benzene / 1.) RT, overnight 2.) 50 deg C, 1 h 5: 85 percent / diisobutylaluminium hydride / toluene / 2 h / -78 °C 6: 1.) potassium tert-butoxide / 1.) DMSO 2.) DMSO 7: 1.) liq. NH3, Na, t-butanol 2.) silica gel / 1.) THF, 15 min; 2.) CHCl3, reflux, overnight View Scheme

lipase from canadida antarcitica T=0 - 50°C; Enzymatic reaction;

lipase from Pseudomonas Cepacia T=0 - 50°C; Enzymatic reaction;

1: 35 percent / methanol; pyridine / 0.33 h / Ambient temperature 2: 85 percent / AcONH4, 15percent aq. TiCl3 / tetrahydrofuran; H2O / 1 h / 60 °C View Scheme

1,1,1,3,3,3-hexamethyl-disilazane in benzene T=20°C; 1.5 h;