5-溴-2-(4-氟苯基)-3-(4-甲基磺酰基苯基)噻吩合成路线 （共 5 条）
反应条件
1: 55 percent / CuI, CF3COONa / N,N-dimethyl-acetamide / 5 h / Heating 2: 48 percent / HNO3, Ac2O / 2 h / 0 °C View Scheme
参考文献
Tsuji, Kiyoshi; Nakamura, Katsuya; Ogino, Takashi; Konishi, Nobukiyo; Tojo, Takashi; Ochi, Takehiro; Seki, Nobuo; Matsuo, Masaaki
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 279 - 286
反应条件
copper(l) iodide; nitric acid; trifluoroacetic acid sodium salt; acetic anhydride 1.) DMA, reflux, 5 h, 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Tsuji, Kiyoshi; Nakamura, Katsuya; Ogino, Takashi; Konishi, Nobukiyo; Tojo, Takashi; Ochi, Takehiro; Seki, Nobuo; Matsuo, Masaaki
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 279 - 286
反应条件
copper(l) iodide; nitric acid; acetic anhydride 1.) DMA, reflux, 5 h, 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Tsuji, Kiyoshi; Nakamura, Katsuya; Ogino, Takashi; Konishi, Nobukiyo; Tojo, Takashi; Ochi, Takehiro; Seki, Nobuo; Matsuo, Masaaki
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 279 - 286
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 12 h; Inert atmosphere;
参考文献
Kallepalli, Venkata A.; Sanchez, Luis; Li, Hao; Gesmundo, Nathan J.; Turton, Clarissa L.; Maleczka Jr., Robert E.; Smith III, Milton R.
Heterocycles, 2010 , vol. 80, # 2 p. 1429 - 1448
反应条件
copper(l) iodide; trifluoroacetic acid sodium salt in N,N-dimethyl acetamide
5 h; Heating;
参考文献
Tsuji, Kiyoshi; Nakamura, Katsuya; Ogino, Takashi; Konishi, Nobukiyo; Tojo, Takashi; Ochi, Takehiro; Seki, Nobuo; Matsuo, Masaaki
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 279 - 286
