(5-溴-2-氧代-2,3-二氢-1H-吲哚-1-基)乙酸乙酯合成路线 （共 2 条）
反应条件
acetic acid; zinc
0.5 h;
参考文献
GILEAD SCIENCES, INC.; ABELMAN, Matthew; CHU, Nancy; JIANG, Robert; ZABLOCKI, Jeff
Patent: WO2011/56985 A2, 2011 ;
Location in patent: Page/Page column 36 ;
WO 2011/056985 A2
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.42 h / 20 °C
1.2: 72 h / 20 °C
2.1: phosphorus pentachloride / N,N-dimethyl-formamide; benzene / 18 h / 80 °C / Inert atmosphere
3.1: zinc; acetic acid / 0.5 h
View Scheme
参考文献
GILEAD SCIENCES, INC.; ABELMAN, Matthew; CHU, Nancy; JIANG, Robert; ZABLOCKI, Jeff
Patent: WO2011/56985 A2, 2011 ;
WO 2011/056985 A2
