8-溴-2-甲氧基-1,5-萘啶合成路线 （共 2 条）
反应条件
phosphorus tribromide in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h;
参考文献
GLAXO GROUP LIMITED; ALEMPARTE-GALLARDO, Carlos; BARROS-AGUIRRE, David; CACHO-IZQUIERDO, Monica; FIANDOR-ROMAN, Jose Maria; LAVANDERA DIAZ, Jose Luis; REMUINAN-BLANCO, Modesto Jesus
Patent: WO2010/81874 A1, 2010 ;
Location in patent: Page/Page column 17-18 ;
WO 2010/081874 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=85°C; Suzuki Coupling;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2009/105232 A1, 2009 ;
Location in patent: Page/Page column 40 ;
US 20090105232 A1
